The Payment Card Industry Data Security Standard (PCI DSS) has expanded its guidance to include numerous security controls for retailers and e-commerce providers. These controls include payment script security, API protection, rapid detection and response to compromised credentials, and regular vulnerability scans. Client-side attacks, such as infostealers and malware, can harvest user credentials and be used for account takeovers and fraud. Web application firewalls (WAFs) are still a strategic security control, but the speed of modern application development requires additional capabilities to dynamically detect and automatically protect endpoints. Attackers constantly retool to bypass defenses, pivoting from web apps to mobile apps or escalating their tactics. The updated PCI DSS includes recommendations for employing targeted risk analysis versus traditional enterprise-wide risk assessments. It addresses the growing threat of client-side attacks with two client-side requirements effective March 31, 2025. Content security policies (CSPs) and subresource integrity (SRI) web methods are difficult to implement and maintain, especially in the e-commerce sector where competition for customer mindshare is driving continuous enhancements to digital experiences. Customers expect seamless and secure transactions, and widely used security controls may not adequately extend protections to client browsers or backend APIs. Bot management solutions that inject user challenges via Captcha are ineffective at deterring sophisticated bots but are effective at frustrating users. To meet PCI DSS compliance mandates, e-commerce providers should consider unified security platforms designed to protect web apps, APIs, and customers throughout the digital life cycle from actual threats targeting their industry.